The FRAP technique allowed detection of distinct mobility changes of Cdc6-YFP during this time. and chromatin-associated during mitosis and G1 phase. It undergoes quick proteasomal degradation during S phase initiation followed by active export to the cytosol during S and G2 phases. Biochemical fractionation abolishes this nuclear exclusion, causing aberrant chromatin association of Cdc6-YFP and, … Continue reading The FRAP technique allowed detection of distinct mobility changes of Cdc6-YFP during this time